Age effect on myopia control efficacy with contrast management spectacle lenses

Deborah Laughton¹, Marcella McParland¹, Jennifer S Hill¹, Lucill Wang¹, Kellie Hogan²
1. SightGlass Vision, Inc, Texas, USA
2. Phoenix Feather Statistics, GA, USA
 

Purpose
To investigate the effect of age on myopia progression amongst Chinese children enrolled in a multicentre randomised controlled clinical trial evaluating contrast management spectacle lenses (Diffusion Optics Technology™, DOT). 
 

Methods
One hundred and eighty-six myopic children aged 6 to 13 years were enrolled in the clinical trial (NCT05562622). Participants were prescribed either DOT spectacle lenses or standard single vision control spectacle lenses in a 2:1 ratio. The cohort was divided into three categories according to enrolment age: Group 1: aged 6-7 (n=27), Group 2: 8-10 (n=101), Group 3: 10-13 years (n=58). Axial Length (AL) and cycloplegic Spherical Equivalent Refraction (cSER) were measured at baseline, 6 and 12 months. 
 

Results
Participant mean age was 9.6±1.8 years; 51.6% female, mean ±SD baseline AL was 24.45±0.80 mm and cSER was -2.27±0.85 D. 

After 12 months, DOT lenses significantly slowed AL progression by 0.26 mm (74%, p<0.0001) and cSER by −0.48D (75%, p<0.0001), compared to control. 

The observed mean changes in both AL and cSER were highest for Group (G)1, followed by G2 and then G3 in the DOT (G1 0.16±0.27 mm, -0.30±0.66 D; G2 0.11±0.22 mm, -0.20±0.46 D; G3 0.03±0.18 mm, -0.04±0.51 D) and control (G1 0.49±0.20 mm, 0.72±0.60 D; G2 0.38±0.16 mm, -0.73±0.37 D; G3 0.23±0.15mm, -0.48±0.36 D) groups. Compared to control lenses, DOT lenses slowed axial elongation (G1 -0.32 mm, p=0.008; G2 -0.27 mm, p<0.0001; G3 -0.20 mm, p=0.0002) and refractive progression (G1 0.48 D, p=0.09; G2 0.54 D, p<0.0001; G3 0.38 D, p=0.004) amongst each age group. 
 

Conclusion
Interim results from this on-going clinical trial demonstrate DOT spectacle lenses slowed axial elongation and myopia progression amongst children aged 6 to 13 years. These results support previous findings that myopia progression is most rapid in younger children (age 6-7 years) and slows with age.